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The risk of late relapse is higher in patients who manifest both indolent and aggressive histologies.[4] While indolent NHL is responsive to immunotherapy, radiation therapy, and chemotherapy, a continuous rate of relapse is usually seen in advanced stages.Patients, however, can often be re-treated with considerable success as long as the disease histology remains low grade.Both lymphomas and lymphoid leukemias are included in this classification because both solid and circulating phases are present in many lymphoid neoplasms and distinction between them is artificial.For example, B-cell chronic lymphocytic leukemia (CLL) and B-cell small lymphocytic lymphoma are simply different manifestations of the same neoplasm, as are lymphoblastic lymphomas and acute lymphocytic leukemias.

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NHL can be divided into two prognostic groups: the indolent lymphomas and the aggressive lymphomas.The Rappaport classification, which also follows, is no longer in common use.

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